Senior Program Manager

What you will do Lead complex, cross-functional product development programs and serve as the program leader for core teams across R&D, Software, Quality, Regulatory, Clinical, and Operations. Drive programs through key development milestones, design reviews, phase exits, clinical trial launch, FPI, and regulatory submission. Translate product goals and regulatory requirements into clear plans, priorities, and decisions that enable teams to execute. Bring cross-functional teams together to resolve technical, operational, and organizational issues and keep programs moving forward. Identify and manage program risks, dependencies, and trade-offs, escalating issues and driving decisions through a formal portfolio governance process when needed. Communicate program progress, risks, decisions, and recommendations to functional and senior leadership. Partner with development teams to ensure product requirements, design controls, risk management, verification/validation, and documentation are appropriately planned and executed. Author and review key product development deliverables, including DDPs, DHF documentation, design review materials, change orders, and other development documentation. Support preparation and execution of IDE, IVDR, 510(k), and other regulatory submissions by coordinating cross-functional deliverables and submission readiness. For CDx programs, partner with CDx development and biopharma partnership teams to align clinical trial assay activities with the broader CDx strategy. Apply strong knowledge of ISO 13485, IEC 62304, design controls, and regulated product development to identify gaps, anticipate risks, and help teams make sound decisions. What you will bring 5-7+ years of experience in program management, product development, or a relevant combination of program leadership and functional experience in diagnostics, medical devices, biotechnology, clinical laboratories, or life sciences. Significant experience leading complex, cross-functional product development programs in a regulated environment. Deep practical understanding of ISO 13485, IEC 62304, design controls, and medical device/IVD development processes. Experience leading teams through design reviews, phase exits, development milestones, and regulatory readiness activities. Hands-on experience with product development documentation, including DDPs, DHF documentation, change orders, requirements, risk documentation, and design review materials. Experience supporting regulatory submissions such as IDE, IVDR, 510(k), PMA, or equivalent. Experience supporting clinical trial execution and readiness through FPI preferred. Experience with assay, software, and systems development; NGS diagnostics and/or MRD experience strongly preferred. Demonstrated ability to influence without authority, challenge assumptions, drive decisions, and resolve issues across functional boundaries. Strong judgment, problem-solving, and communication skills, with the ability to operate effectively in a fast-paced and sometimes ambiguous environment. A hands-on, execution-oriented mindset and willingness to personally contribute to critical program and product development deliverables. PMP certification or equivalent preferred. Compensation & Total Rewards This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations. This position is also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including: Comprehensive health benefits (medical, dental, vision) 401(k) with company match Generous paid time off and company holidays Additional wellness and work-life benefits Compensation Range $$119,000.00 - $148,700.00 OUR OPPORTUNITY Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management. WHAT WE OFFER Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program! For more information, visit www.natera.com . Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide. All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws. If you are based in California, we encourage you to read this important information for California resid